Endocrine Abstracts

Osteoporosis and associated fractures are the most common and debilitating complication of glucocorticoid use. The use of alternative anti-inflammatory agents without the catabolic and deleterious skeletal side-effects of glucocorticoids is needed. Dehydroepiandrosterone (DHEA) may have immunomodulatory as well as positive effects on bone. To further our understanding of the mechanisms of action of DHEA, as a steroid-sparing agent, we investigated and compared the effects of D...

Adipose tissue is recognized as an active endocrine organ. Cytokines released from adipocytes induce chronic low-grade inflammation, which is linked to the development of cardiovascular diseases and malignancy.In this study, we examined the relationship between baseline adipokines level and incident cancer risk in a community-based cohort of Chinese subjects. Subjects were recruited from the Hong Kong Cardiovascular Risk Factors Prevalence Study 2(CRISPS 2) cohort. Those with ...

Objectives: Obesity is associated with an increase in cardiovascular risk. We investigated whether the measurement of obesity-related biomarkers could enhance the prediction of cardiovascular (CVD) events when used in conjunction with traditional risk factors.Methods: We studied subjects in the Hong Kong Cardiovascular Risk Factors Prevalence Study 2 (CRISPS 2) cohort without previous cardiovascular disease. Baseline serum levels of several biomarkers kn...